Just when Cleveland's quarterback conundrum seemed settled, a new development.
Hoyer had taken the starting job from Weeden, who sprained his thumb in Week 2 and was only cleared to play this week. Chudzinski decided to stick with Hoyer, but will now have to go with Weeden, who threw a 37-yard TD pass to Josh Gordon in the third quarter to rally the Browns, who trailed 10-0 in the first half and 24-17 in the third quarter.
Hoyer's injury wasn't the only significant one as Manuel also sprained his knee, Bills wide receiver Stevie Johnson hurt his back and Browns defensive end Desmond Bryant was hospitalized with shortness of breath.
Here are five things we learned in watching the Browns take over sole possession of first in the AFC North with their win over the Bills.
MANUEL LABOR: Like Hoyer, Manuel was injured on a running play.
At the end of a 14-yard pickup, Manuel was whacked on his right knee by the helmet of Browns safety Tashaun Gipson, who seemed to be a nuisance to the Bills all evening.
Following the game, Bills coach Doug Marrone was drilled by reporters about whether he would prefer Manuel to run out of bounds and not risk injury.
"E.J.'s a tough kid. He took a shot, he scrambled, he made a first down, he was trying to score a touchdown," Marrone said. "What do you say? 'Don't scramble, don't score touchdowns.'"
RUN, TRAVIS, RUN: Browns return specialist Travis Benjamin broke some tackles and a record with a magnificent performance.
Benjamin returned a punt 79 yards for a touchdown in the first half, a dazzling run in which he outran some Bills defenders, avoided others with his shiftiness and ran through a couple tackles. He was a blur wearing brown.