Manning finished 28 for 42 for 295 yards, but lost two fumbles and threw a pick-6 — a 59-yard interception return by Paul Posluszny that pulled the Jaguars (0-6) within 14-12 at halftime.
It was a two-point game late in the third quarter, before Moreno scored his last touchdown, an 8-yard run, for a 28-19 lead. Moreno finished with 42 yards.
Justin Blackmon had 14 catches for 190 yards for Jacksonville.
CHIEFS 24, RAIDERS 7
KANSAS CITY, Mo. (AP) — Jamaal Charles ran for two touchdowns, the Kansas City defense harassed Oakland quarterback Terrelle Pryor into throwing three second-half interceptions and the Chiefs remained unbeaten.
After winning just twice last season, Kansas City (6-0) continued the second-best start in franchise history. The Chiefs won their first nine games during the 2003 season.
The Chiefs piled up 10 sacks while ending a three-game skid to the Raiders (2-4), and a six-game losing streak against them at Arrowhead Stadium.
Pryor threw for 216 yards and a touchdown, but his interceptions proved costly.
The first led to Charles' go-ahead touchdown run, the second led to Ryan Succop's fourth-quarter field goal, and Husain Abdullah returned the last one for a touchdown to seal the win.
COWBOYS 31, REDSKINS 16
ARLINGTON, Texas (AP) — Dwayne Harris returned a punt 86 yards for a touchdown and set up another score with a 90-yard kickoff return and Dallas handed Robert Griffin III his first loss in his home state with a victory against Washington.
Tony Romo had just 170 yards passing a week after getting 506 in a wild 51-48 loss to Denver.
That's because Harris had 222 total return yards and Kyle Wilber forced and recovered a fumble on a sack of Griffin that left the Cowboys needing just 3 yards for a clinching score in the fourth quarter.
The Cowboys (3-3) gave owner Jerry Jones a win on his 71st birthday.
Dallas kept the defending NFC East champion Redskins (1-4) from building any momentum after a win and a bye following an 0-3 start.