Rookie safety Eric Reid made his team-leading third interception and also recovered a fumble to stop an Arizona drive deep in 49ers territory in the third quarter. San Francisco forced four turnovers for the second straight game.
Arizona (3-3) lost star defensive end Calais Campbell to an apparent right leg injury late in the game.
RAMS 38, TEXANS 13
HOUSTON (AP) — Sam Bradford threw three touchdown passes, St. Louis added a score on defense and special teams and the Rams stunned mistake-prone Houston.
The Rams (3-3) were up 24-6 early in the third quarter before rookie Daren Bates returned Keshawn Martin's fumble on a kickoff return for a touchdown.
Alec Ogletree pushed the lead to 38-6 when he took an interception by T.J. Yates back 98 yards for a touchdown. Yates was in after Matt Schaub sustained an apparent right ankle injury.
Schaub didn't have a turnover after throwing six interceptions, three of them returned for touchdowns in the past three games.
But several other Texans had key gaffes as preseason Super Bowl hopeful Houston (2-4) lost its fourth straight game.
SEAHAWKS 20, TITANS 13
SEATTLE (AP) — Marshawn Lynch ran for two touchdowns and had 155 all-purpose yards, Richard Sherman came up with his third interception of the season, and Seattle finally shook Tennessee in the fourth quarter.
Seattle (5-1) won its 11th straight at home despite a long list of mistakes that allowed the Titans (3-3) to hang around into the fourth. There was a careless turnover, missed defensive assignments and a comical muffed field goal attempt that led to the Titans' only touchdown on the final play of the first half.
But the Seahawks made enough plays thanks to Lynch, quarterback Russell Wilson and Sherman's interception to remain on top of the NFC West. Lynch had TD runs of 3 yards and 1 yard.
BENGALS 27, BILLS 24 OT