Jonathan Papelbon was perfect in the ninth for his 22nd save in 28 opportunities.
Wheeler (6-3) worked 6 2-3 impressive innings in his 13th big league start. New York lost for just the second time in his last 10 outings. The rising star gave up two runs and five hits, and threw 105 pitches.
DODGERS 6, CUBS 2
LOS ANGELES (AP) — Zack Greinke came within one strike of his fifth career shutout, Hanley Ramirez and Yasiel Puig homered, and the Los Angeles Dodgers defeated the Chicago Cubs, ending a two-game skid.
The Cubs lost for the eighth straight time to the Dodgers, including a four-game sweep at Wrigley Field earlier this month. The Dodgers equaled their longest winning streak against the Cubs in franchise history, set from June 9, 1974-May 19, 1975.
Greinke (13-3) tied his season high with nine strikeouts and he walked two while improving to 5-0 this month. The right-hander has won 10 of 11 decisions since June 22.
Greinke had a two-out hit in the fourth that scored the Dodgers' first run.
After giving up a single to Starlin Castro to open the game, Greinke retired the next 13 batters before Donnie Murphy singled in the fifth.
Greinke got the first two outs of the ninth before running into trouble. Brian Bogusevic's RBI double scored Chicago's two runs. Brian Wilson came in to strike out Murphy for the final out.
Jake Arrieta (1-1) gave up four runs and six hits in five-plus innings in his first road start for the Cubs.
ROCKIES 6, GIANTS 1
DENVER (AP) — Todd Helton homered to move within three hits of 2,500, and Colorado beat San Francisco.
Juan Nicasio tossed six shutout innings and added an RBI single, and Charlie Blackmon also homered for the Rockies.
Buster Posey singled and reached base for the 49th straight game against Colorado.
The Rockies began a nine-game, 10-day homestand with a strong performance against lefty Barry Zito (4-10), who has struggled away from home this season. Zito allowed five runs and nine hits and struck out one in four innings in his second start since being put back into the rotation. He is 0-8 with a 9.61 ERA on the road this season.