St. Louis' hard-throwing bullpen combined for one-hit relief. Carlos Martinez got six outs, retiring Mike Napoli on an inning-ending popup with two on in the eighth. Trevor Rosenthal struck out the side on 11 pitches in the ninth for a save, whiffing Daniel Nava with a 99 mph fastball to end it.
Seeking its second championship in three seasons, St. Louis improved to 7-0 this postseason when scoring first and stopped Boston's World Series winning streak at nine. That run began with a sweep of the Cardinals in 2004, when St. Louis never led the entire Series.
This year's opener was more of the same, when the Cardinals made three errors and the Red Sox romped 8-1.
Lackey, pitching a day after his 35th birthday, returned this year after missing all of 2012 due to elbow surgery. In his first Series appearance since his Game 7 win 11 years earlier, he couldn't hold the lead Ortiz gave him with his 17th postseason homer, his fifth this year.
"We've got to go out there and play better than we did tonight," Ortiz said. "Nobody can dictate that you're going to win four straight games every time you go out there for the World Series."
NOTES: The Red Sox had not lost in the Series since Game 7 in 1986 against the New York Mets. ... With no DH allowed in the NL ballpark, Boston manager John Farrell said Ortiz will likely play first base in Game 3. Napoli would sit. ... Victims of the Boston Marathon bombings were honored during the seventh-inning stretch as singer James Taylor led the crowd in "America the Beautiful."